Equilibrium Unfolding Thermodynamics of β2-Microglobulin Analyzed through Native-State H/D Exchange
نویسندگان
چکیده
منابع مشابه
Influence of heparin molecular size on the induction of C-terminal unfolding in β2-microglobulin
Dialysis-related amyloidosis (DRA) is characterized by accumulation of amyloid β2-microglobulin (β2m) in the interstitial matrix. Matrix substances such as heparin have reportedly been strongly implicated in the pathogenesis of dialysis-related amyloidosis. In clinical setting of hemodialysis, two types of heparin, i.e., high and low molecular heparin (H.M.H. and L.M.H.) have been routinely use...
متن کاملinfluence of heparin molecular size on the induction of c-terminal unfolding in β2-microglobulin
dialysis-related amyloidosis (dra) is characterized by accumulation of amyloid β2-microglobulin (β2m) in the interstitial matrix. matrix substances such as heparin have reportedly been strongly implicated in the pathogenesis of dialysis-related amyloidosis. in clinical setting of hemodialysis, two types of heparin, i.e., high and low molecular heparin (h.m.h. and l.m.h.) have been routinely use...
متن کاملInfluence of heparin molecular size on the induction of C- terminal unfolding in β2-microglobulin
Dialysis-related amyloidosis (DRA) is characterized by accumulation of amyloid β2- microglobulin (β2m) in the interstitial matrix. Matrix substances such as heparin have reportedly been strongly implicated in the pathogenesis of dialysis-related amyloidosis. In clinical setting of hemodialysis, two types of heparin, i.e., high and low molecular heparin (H.M.H. and L.M.H.) have been routinely us...
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The thermodynamics of folding and unfolding of a beta-heptapeptide in methanol solution has been studied at four different temperatures, 298 K, 340 K, 350 K, and 360 K, by molecular dynamics simulation. At each of these temperatures, the 50-ns simulations were sufficient to generate an equilibrium distribution between a relatively small number of conformations (approximately 10(2)), showing tha...
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Background: Hydrogen/deuterium exchange detected by mass spectrometry (HDX-MS) is an experimental technique that provides valuable information about a protein’s structure and dynamics. Data produced by HDX-MS experiments is often interpreted using a crystal structure of the protein. However, it has been suggested that more accurate interpretations can be derived from conformational ensembles pr...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2009
ISSN: 0006-3495
DOI: 10.1529/biophysj.108.142448